Hostess ran a series of ads featuring Marvel characters in comics throughout the 1970s and early 1980s that decades later I still indelibly associate with Cupcakes, Fruit Pies and Twinkies. Marvel comics dated April 1980 featured the Human Torch in A Hot Time in the Old Town in which the hero fights Flame Thrower in order to save New York City from a fiery end! Thank goodness the Torch is able to distract the villain with Hostess Twinkies! Click on the image below for a high-resolution copy of the ad.
Source: Kraalo Archives